I know small nanos are usually run without a skimmer since water changes removes the nitrates. My understanding is that everyones setup is unique, and what works for one may not work for another.
I've done it before, but as Mrktplayer said it really depends on what type of system you have, what livestock you want, etc. I've run nanos that way, but did huge water changes. Also had a dwarf seahorse tank that I never skimmed, but I wanted the excess macro growth.