How stable is your tank. What I mean is how often do you "adjust" you Ca++? You can go above 450 and have it slowly drop until you get back. I would do a good sized water change, slowly increase your dosing, I am assuming that you are using a two part buffer and have a relaxing vacation. I would be more concerned with my tank sitter overfeeding or my heaters going crazy. have a nice vacation.
Walter
Walter