I've got 2 Eclipses running here at home, a 5g and a 25g. The 5 has been running since January and the 25 since February.
Out of sheer laziness I have not removed the biowheels but have no significant nitrates (under 5 ppm which is consistent with my Berlin style 55 that has no filtration, except a kick-butt skimmer). Both tanks have at least 1 lb per gallon of dense Fiji rock.
IMO if you've got enough dense LR to perform the anaerobic part of the cycle, the biowheel will neither hinder nor harm.
While bio-wheels and bio-balls are often referred to as "nitrate factories", I think this is a bit of a misnomer. The media themselves do not PRODUCE the nitrate (as a factory produces products) but rather they harbor nitrates, a byproduct of the bacterial breakdown of wastes. Over time, there is not enough anaerobic activity within them to break the nitrates down into nitrogen gas, and that's where they falter.
Either way, if you've got enough flow and enough live rock in your tank, you shouldn't notice a difference either way.
One good thing about bio-wheels is if you want/need to get another tank going in a hurry, and the bio-wheel is the same size on the new tank as the old, you can swap an established biowheel into the new tank, and have virtually "instant" cycled tank.
HTH
Jenn