I used to have inline and now owns drop ins. The biggest drawback I have for the inlines are reduced flow thru rate probably due to accumulated detritus coating the tubes inside the chiller, which makes chilling less efficient, in theory. I tried to use brush to clean the tubes inside, I can see lots of stuffs comes out with the brush, but the awkward position of the inlet and outlet and close proximity to electrical components, I cannot do a flush to thoroughly clean it.
In comparison, I prefer the drop-in's for ease of cleaning. But beware, the drop-in coil is bigger then I think they are and take up quite a significant amount of space in the sump. It's not just the coil space you need to allocate, but also the big thick tube that attaches to the coil that's also taking up space.
I still prefer the drop-in's.