My 125G system is 2.5year now. My bioload is fairly high.
Used to run it skimmerless during the first 2 years and doing 25% monthly water change. I observe a consistent trend that towards the 4th week, fishes respiration rate increases, sometime to the point that make me change the water and run carbon without waiting for the week to end.
After adding the skimmer for the last six months, this trend disappeared.
The amount of gunk pulled out daily convinced me the refugium alone is inadequate.
I felt running both skimmer and refugium together produce more effective filtration - in my case, the bioload is quite high.
I believes if the bioload is light, skimmerless will be OK with proper maintenance.
My understanding is, skimmer removes proteins before it breaks down into ammonia>nitrite>nitrate.
However, it is not possible to remove all of the proteins, hence, the refugium come into play to remove the rest of the waste products.
Happy reefing
