Thats a tough one, it depends on what type of nano or larger tank you want to set up. The general myth is that nanos are a lot harder and require a lot more effort than larger, more forgiving setups. I think this is true in some cases, but definitely not all. You could put a lot of effort into building an amazing little self contained pico like brandon's, or you could just buy a nanocube and run it as is or with a few small mods. But if you were to compare similar setups, like say a 90 gallon soft coral and LPS tank to a ten gallon soft coral and LPS tank, you will in general save money on the nano. I found that setting up my nano was easier than my bigger tank simply because there was less to do. Less sand and rock to put in and arrange, less water to fill and to change, fewer powerheads to deal with, and no skimmer. But if you wanted to set up an SPS/clam nano, you might want halides, a skimmer, and refugium, which add cost and effort. In general though, I don't think nanos are harder than larger tanks, as they are commonly thought to be. So if you're doing this poll to decide if you want to step into the world of nanos, I encourage you to do it. It's different, but a lot of fun and I'm sure you'll be hooked like the rest of us