The problem kinda is that the silicones that work for glass don't work well for acrylic and vice versa. Acetoxy cure silicones such as GE Silicone I work great for glass but don't stick well at all to acrylic while neutral cures like GE Silicone II works *okay* for acrylic but not well for glass. If just for baffles, it's fine though.
Personally I'd shy away from 100% silicones, use "silicone adhesives" such as Dow Corning #795, it costs more, harder to find, and takes longer to cure but sticks well to acrylic. It's what we use for pressure gaskets in public aquaria where we are sticking acrylic to fiberglass or coated concrete.
HTH,
James